Anticonvulsants or antiepileptic drugs aeds are used to stop an ongoing seizure or to decrease the frequency or severity of anticipated future seizures during a seizure episode or status epilepticus the route of administration for aeds is iv see table drugs used for treatment of status epilepticus. In particular antiepileptic drugs have many serious reactions as seen with carbamazepine cbz valproic acid vpa and phenytoin pht though relatively rare when compared with other consistently known hepatotoxic drugs the hepatotoxicity induced by antiepileptic drug can lead to death or an acute liver failure which could imperatively require liver transplantation the hepatotoxicity . Maintenance antiepileptic drugs anticonvulsants in dogs phenobarbital and bromide are considered first line maintenance aeds but levetiracetam and zonisamide are often used as well in cats phenobarbital is the usual first choice but levetiracetam and zonisamide are becoming more acceptable diazepam is an alternative choice. Basic clinical pharmacology katzung masters trevorpdf mcgrawhill education niqui salido download pdf download full pdf package this paper a short summary of this paper 21 full pdfs related to this paper read paper basic clinical pharmacology katzung masters trevorpdf download basic clinical pharmacology katzung masters trevorpdf niqui salido . A valproate has been shown to inhibit glucuronidation and decrease the apparent clearance of lamotrigine see drug interactions clinical pharmacology b drugs that induce lamotrigine glucuronidation and increase clearance other than the specified antiepileptic drugs include estrogen containing oral contraceptives rifampin and the
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